Migraine Medication Might Be Used To Deal with Weight problems, Says Research

Based on a brand new examine by scientists at UT Southwestern, a generally prescribed class of migraine medication referred to as Triptans can be utilized in treating weight problems. On July 7, the workforce of researchers reported within the Journal of Experimental Medication that, within the examine on overweight mice, a dosage of triptan day by day made animals eat much less meals and shed weight in over a month’s interval. “The examine outcomes could possibly be very important for drug improvement,” mentioned examine chief Chen Liu, Ph.D., Assistant Professor of Inside Medication and Neuroscience. The examine was financed by the Nationwide Institutes of Well being (R01 DK114036, DK130892, F32DK116427, K01AA024809), and the American Well being Affiliation (16SDG27260001). 

To conduct the examine, the researchers examined six prescription triptans in overweight mice that got a high-fat weight-reduction plan for round 7 weeks. The mice got two of those medication in considerably related quantities, however mice that got the opposite 4 consumed much less. After 24 days, mice that got a dose of the drug frovatriptan day by day had misplaced 3.6% of their physique weight on a mean, alternatively, mice not given a triptan gained 5.1% of their physique weight. Dr. Liu and his workforce noticed related outcomes after they induced units into the animals that gave them a balanced dose of frovatriptan for twenty-four days.

Additionally learn: Weight Administration Ideas: Know-How Resting Will Help Higher Weight Loss

It was discovered {that a} day by day dose of triptan led animals to eat much less meals and drop some weight over the course of a month. The examine additionally suspects that sufferers wouldn’t have observed the longer-term impacts of triptans on urge for food and weight because it’s typically prescribed for short-term use throughout migraines. There are 15 totally different serotonin receptors, and molecules which can be delicate in the direction of serotonin and alert for cells to switch their conduct as a response. Triptans principally perform by focusing on a receptor referred to as serotonin 1B receptor. This receptor was not beforehand nicely studied within the context of urge for food and weight reduction.

Research chief Chen Liu, Ph.D., Assistant Professor of Inside Medication and Neuroscience and an investigator within the Peter O’Donnell Jr. Mind Institute, mentioned, “We’ve proven that there’s a good probability to make use of these medication, that are already thought of secure, for treating weight problems.” He additional added saying, “We concluded that these medication, and one particularly, will help in decreasing physique weight and boosting glucose metabolism in lower than a month, which is sort of formidable.”